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For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]
I found a few pubs by Pickart on PubMed
The thymus function is linked to the risk of various diseases, and as the thymus function decreases, the risk of diseases like cancers, heart disease, and autoimmunity increases 16m30s
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In particular, preclinical studies have demonstrated that GLP-1 and its more stable and long-lasting analogues GLP-1RAs possess neuroprotective and antiapoptotic properties, modulate long-term potentiation and synaptic plasticity, as well as promote the differentiation of neuron precursors, and can reduce depressive behavior [75]
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